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Mechanisms

Work strand 5

Photo of Professor Phil Chowienczyk
Defining mechanisms: interventional studies to test specific pathways

Lead: Prof. Phil Chowienczyk (King’s College London)

Whilst workstrand 4 may identify potential BP response genes from genetic analysis of a metabolite signature associated with a BP response, workstrand 5 will probe pathways directly to determine the organs involved, and how these relate to differential response to first-line anti-hypertensive drugs.

The initial phase of this work strand will focus on pathways identified from previous work including our preliminary multi-omics analysis which is thought to be implicated in ethnic differences in vascular physiology. Thus nitric oxide synthase (NOS) has been implicated in hypertension and BP response from GWAS and target sequencing, our analysis of metabolites associated with arterial stiffness and previous associations with diuretic response.

Share your comments on “your life with hypertension” and/or your experience of AIM HY INFORM Clinical Trial.

” I was diagnosed with high blood pressure more than 10 years ago. In August 2015, I had a Coronary Angioplasty surgery when three stents were inserted in one of my heart’s arteries. My symptoms improved a bit but not significantly. In August 2017, I saw an advert inviting people to participate in the AIM HY programme. I hurriedly offered myself as a guinea-pig. I have only started the first round of dual therapy and believe me, I am feeling so much better.

For the first time in many years, I ran to catch a bus without feeling short of breath. I have opted to be an ambassador of this programme because it is effective.

If you would like to leave a comment related to your treatment or the AIM HY INFORM trial experience, please click here. 

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